Abstract: Deep-water steel pipe pile-concrete wall composite structure is often used as the temporary revetment of the buried section and dock entrance of immersed tunnel. The particularity of its environment and structure type brings in difficulties for mechanical demolition. The key to ensure the opening of the dock channel is to study the influence of the blasting demolition of concrete waterproof wall on the dynamic characteristics of adjacent steel pipe piles. Based on the blasting demolition engineering of the immersed tube butt end and dry dock gate waterproof wall in the Xiangyang East-West Axis Road Project, a coupled Eulerian-Lagrange method was used to establish the three-dimensional refined numerical model of the steel tube piles-concrete wall, and the dynamic characteristics of steel tube piles at varying blasthole positions (pile side charge holes and charge holes between piles) was analyzed. Results show that the locking steel pipe pile will not collapse under different hole layout forms, but the case with charge holes between piles is more beneficial to shearing bolts, which can achieve the blasting effects of “rupture and collapse of the demolition object”, “breaking without collapse of the retained object”, and “zero interference to the surrounding environment”.