Abstract: The blasting construction may cause potential risk to adjacent buildings. In order to reduce the risk effectively or even eliminate it, the accurate prediction of the influence of blasting construction is of much importance. Therefore, to ensure the stability of an adjacent pile wharf, a three dimensional nonlinear finite element model for the whole area of the blasting location and the high-pile wharf is established before the blasting construction around the wharf. Afterwards, under the effect of the blast loading and the most unfavorable load of high-piled wharf during service, the dynamic response of the nonlinear interaction between the internal structure of the harbor and the soil is calculated and analyzed. In line with the dynamic response which caused by the shock wave and delivered through soil that the wharf structure can withstand, and taking safety vibration velocity of the high pile wharf as the measuring standard, the biggest dosage of the single blast hole closest to the wharf is obtained. In the mean time, the displacement, bending moment, shear force and strain of the wharf are analyzed. According to the result, the displacement of the wharf under blasting load is of little influence, while the inclined piles inside the wharf bear more stress and shear force than the vertical piles. In conclusion, inclined piles are more vulnerable in the blasting construction.