Abstract: In order to guarantee the safety of China’s water, energy and food, the pressure state response model was applied to evaluate the safety of water-energy-food nexus system in China from 2007 to 2016. 16 representative indexes were selected to construct a collaborative safety evaluation index system of water-energy-food nexus. The analytic hierarchy process (AHP) was used to determine the index weight. Based on data during 2007－2016, the safety of water-energy-food nexus system was assessed at national and provincial levels. The results show that the collaborative security degree of water-energy-food nexus system in China has been rising in the past 10 years. The comprehensive collaborative security degree of water-energy-food nexus system in Beijing, Tianjin and Shanghai is higher than others. However, Ningxia, Xinjiang and Chongqing have low degree of collaborative cooperative security due to shortage in water resources. The level of comprehensive collaborative security in most provinces is higher during 2012－2016 than that in 2007－2011.