Abstract: Urban waterlogging has become an important disaster that threatens people’s lives and property. As China enters the era of “stock planning”, urban renewal has become an important way to optimize spatial layout and solve urban problems. Existing studies have shown that land expansion and land use layout are important causes of urban waterlogging. The optimization of urban space layout has positive significance for alleviating waterlogging. Aiming at the innovation of the application mode of urban layout optimization in urban renewal planning under waterlogging prevention, we proposed an urban renewal planning path for alleviating waterlogging by constructing an urban spatial layout optimization model. Taking Foshan, China as an example, the model reduced the impact of urban building layout on surface runoff by 18.11% on average. The optimization process did not change the surface space on a large scale. An urban renewal planning model for alleviating waterlogging was proposed. The above work is expected to be realized through the control of total building density and the adjustment of urban surface layout in urban renewal planning work.