Abstract: With the global warming, the sea level is rising at an accelerated rate. The Yangtze River estuary, located in the northwest edge of the storm basin in the northwest Pacific Ocean, with a low-lying terrain, is assessed as a vulnerable area under the impact of storm surge disasters. In order to study the changes of storm tide levels in the reach below Jiangyin of the Yangtze River after sea level rise, a refined mathematical model was established for the astronomical tide-storm surge coupling in the Yangtze River estuary. The model simulated and analyzed the response law of astronomical tides and storm surge near the Yangtze River estuary after sea level rise under the action of two typical typhoons, No.9711 (Winnie) and No.1509 (Chan-hom). The study shows that in the next 100 years, the average tidal level of the Yangtze River estuary will rise by 50~80 cm after the sea level rises by 70 cm. The extreme value of water increment in the reach below Jiangyin and near the shore area of the Yangtze estuary will decrease slightly. The extreme value of water increment will first increase and then decrease from Jiangyin in the upstream to Niupi Reef in the downstream. The specific location along the way of the extreme value of water increase is closely related to the typhoon path and typhoon intensity. The study can provide a theoretical basis for flood control and waterlogging drainage of towns along the Yangtze River estuary in the medium and long term.