Abstract: The complex coupling relationship exists between water resources, economic society and ecological environment, and promoting the coupling and coordination of the three is an important prerequisite for achieving sustainable regional development. Based on the coupling coordination degree model, we measured the coupling coordination degree of water resources-economic society-ecological environment system in 14 cities and states of Gansu Province from 2010 to 2019, and analyzed the evolution characteristics of the coupling coordination degree by combining with the evolution model of center of gravity. The results show that (1) the overall water resources-economic society-ecological environment comprehensive evaluation index of Gansu Province showed a slight upward trend during 2010-2019, and its spatial distribution was consistent with the distribution pattern of water resources endowment, economic and social development and ecological environment management in each city and state; (2) the coupling coordination degree of the three systems in Gansu Province was between 0.52,0.54, which belonged to the basic coordination type, and the spatial dimension of the coupling coordination type of each city (state) was either stable or improving; (3) the trajectory of the center of gravity of the coupling coordination degree from 2010 to 2019 was mainly in Lanzhou City, with an average annual distance of 7.19 km. A differentiated strategy should be adopted to promote the evolution of water resources-economic society-ecological environment towards advanced coupling coordination.