Abstract: Revealing the main influencing factors of coupled water resources-economic society-ecological environment coordination is important for strengthening the macro management of natural resources and economic society systems as well as promoting regional sustainable development. With the selection of indicators based on two dimensions of endogenous and outward dynamics, this study introduces a fixed-effects model to measure the coupled water resources-economic society-ecological environment coordination drivers in Gansu Province from 2010 to 2019 by analyzing the evolution of regional water resources-economic society-ecological environment coupling. The results show that: ① The level of economic development and technological development have a positive effect on the improvement of the level of coupled water resources-economic society-ecological environment coordination in Gansu Province, with regression coefficients of 0.029 and 0.021 respectively, and passing the 1% significance test. ② The factors influencing the zoning areas differ significantly, the improvement of the level of environmental protection and economic development has a catalytic effect on the improvement of the coupling coordination of the sub-regions. In the context of accelerating economic society development in Gansu Province, policies and incentives of relevant drivers should be coordinated to promote the coupled evolution of water resources-economic society-ecological environment system.