Abstract: Playing an important role in the water supply system of the Huangpu River in Shanghai, the water quality in the Jinze reservoir is significant for the drinking water security of the Shanghai city. Since the water of the Jinze reservoir mostly comes from the Taihu Lake, the water quality in the Jinze water source area is influenced by the operation schemes of the Taipu sluice, which is located at the mainstream of the Taipu River and controls the water from the Taihu Lake. After analyzing the observed hydrological data of the Taipu River, it is found that there exists a sensitive water quantity & quality response relationship between the Jinze water source area and the Taipu sluice. For the Jinze water source area, when the discharge from this sluice increases, water from the Taihu Lake increases, and that from the tributaries of the Taipu River decreases. Thus, the concentration of key water quality indicators at the Jinze water source area is reduced. Furthermore, to improve the water quality at the Jinze water source area, the water quantity and quality joint operation schemes for the Taipu sluice are designed. By simulating the water quantity and quality, the water quality improvements at the Jinze water source area are analyzed. The analysis results show that the water quantity and quality joint operation for the Taipu sluice can effectively improve both the water level and the key water quality indicators of the Jinze water source area.