Abstract: As the main water-conveyance line of the east route of the South-to-North Water Diversion Project, the seepage and structural safety of the Li Canal are of great significance to ensuring the operation of the east route of the South-to-North Water Diversion Project and the safety of the lives and property of the residents along the line. In view of the seepage and structural safety problems existing in the main dangerous sections of the Li Canal levee project, the main risk factors affecting the project safety are systematically analyzed, and the possible failure modes of the earth levee, sluices and culverts of the Li Canal levee project are put forward. Based on the results of the project investigation and safety inspection, the seepage and stability calculation of the typical dangerous sections of the Li Canal levee is carried out in this study. According to the guidelines for the levee safety evaluation, the safety grade of seepage and stability of the Li Canal east levee is determined, and the comprehensive safety evaluation for the typical dangerous sections is carried out. There are serious potential safety hazards in the Li Canal east levee, which is comprehensively evaluated as the third type of levees. The analysis with research results can provide a basis for reinforcement, monitoring and design of the Li Canal levee.