Abstract: Since 1980s, along with the social and economy development in the north of Jiangsu Province, the status of the Guanhe River estuary and its adjacent sea area has became more and more important. A lot of researches on this area have been carried out by the related management departments and scholars. The complex nature conditions and large-scale estuarine regulation works lead to unnegligible temporal and spatial variations of the marine hydrology and marine environment in the Guanhe River estuary. Therefore, many literatures with findings of the engineering environmental oceanography and marine environmental ecology in the Guanhe River estuary from 1980 were summarized systemically, and the hydrologic data measured in 2007 were also adopted for some discussions in this paper. In the general, several problems including spatially variation of tidal range, variation of the spring-neap tide having deferent velocities, variation of the entrance bar, estuarine front, variation of sediment transport induced by the training jetties, assessment of major pollutants inflow volume into the estuarine waters and the marine environment capacity, environmental dynamics and ecological dynamics, the relationships between the temporal and spatial variations of the heavy metal concentrations in the nearshore sediment, the plankton organism and the large-sized regulation works located out of estuary still need to be further studied in the future. Research results show that this study can provide a technical reference for studies and development of the Guanhe River estuary.