Natural river channels generally cannot meet the actual requirements of local navigation. Therefore, the waterway regulation is the key technology to meet people's requirements. Currently, the regulation technology of the inland waterway in China is very mature, but there is still little research on river channels with continuous bends and abundant dangerous beaches. This research is based on the river channel with beaches in the lower reaches of the Changsheng wharf of Baiyin City of the upper reaches of the Yellow River. The river channel belongs to a continuous curved channel. There are many beach bodies in this river channel with complex water flow conditions, which seriously affects the safe navigation of ships. Taking the numerical simulation as the research means, a two-dimensional mathematical model is established to analyze the hindering factors of the river channel, demonstrate the rationality of the regulation scheme, and determine effective regulation methods, including filling trough, cutting nozzle, dredging, and constructing submersible dam, etc. The regulation effect is very obvious. The hydraulic factors reach the navigation index, and the flow conditions are obviously improved, which provides a reference for future regulation projects of the upper reaches of the Yellow River as well as the waterway with similar navigation hindrance characteristics.