Taking the lower approach channel of the Wuliting navigation lock as a case history. A two-dimensional hydrodynamic model is developed to study regulation measures, such as riverbank excavation, construction of the guild walls, dredging and adjustment of waterway regulation. The gradual optimization of water flow conditions of the typical approach channel is expounded in detail, and the recommended regulation schemes for the downstream approach channel of the Wuliting navigation lock are proposed based on the analyses above. Through the gradual optimization of the schemes, the main conclusions are as follows: ① The optimization process of the comprehensive channel regulations is a gradual process under multi constraints. Both the feasibilities of hydropower generation and flood propagation should be considered before the regulation measures of navigation are adopted, which is usually ignored; ② There should be an optimal length of the guild walls for certain approach channels; ③ The construction of a long submerged guild wall is suggested, not only appropriate for the navigation conditions but also for the hydropower generation and flood carrying capacity. It is an effective measure to remedy the poor navigational flow in approach channels of the navigation locks.